Publications

  • Sharifi, S., and Bierhoff, H. (2018). Regulation of RNA polymerase I transcription in development, disease and aging. Annu Rev Biochem doi: 10.1146/annurev-biochem-062917-012612. [Epub ahead of print]
  • Bierhoff, H. (2018). Analysis of lncRNA-Protein Interactions by RNA-Protein Pull-Down Assays and RNA Immunoprecipitation (RIP). Methods Mol Biol 1686, 241-250.
  • Brocks, D., Schmidt, C.R., Daskalakis, M., Jang, H.S., Shah, N.M., Li, D., Li, J., Zhang, B., Hou, Y., Laudato, S., Lipka, D.B., Schott, J., Bierhoff, H., Assenov, Y., Helf, M., Ressnerova, A., Islam, M.S., Lindroth, A.M., Haas, S., Essers, M., Imbusch, C.D., Brors, B., Oehme, I., Witt, O., Lubbert, M., Mallm, J.P., Rippe, K., Will, R., Weichenhan, D., Stoecklin, G., Gerhauser, C., Oakes, C.C., Wang, T., and Plass, C. (2017). DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat Genet 49, 1052-1060.
  • Zhao, Z. and Bierhoff, H. (2017). Nucleosome Positioning Assay. Bio-protocol 7(10): e2285. DOI: 10.21769/BioProtoc.2285
  • Evsyukov, V., Domanskyi, A., Bierhoff, H., Gispert, S., Mustafa, R., Schlaudraff, F., Liss, B., and Parlato, R. (2017). Genetic mutations linked to Parkinson’s disease differentially control nucleolar activity in pre-symptomatic mouse models. Dis Model Mech 10, 633-643.
  • Schnöder, T.M., Eberhardt, J., Koehler, M., Bierhoff, H.B., Weinert, S., Pandey, A.D., Nimmagadda, S.C., Wolleschak, D., Johrens, K., Fischer, T., et al. (2017). Cell autonomous expression of CXCL-10 in JAK2V617F-mutated MPN. J Cancer Res Clin Oncol 143, 807-820.
  • Zhao, Z., Dammert, M.A., Hoppe, S., Bierhoff, H., and Grummt, I. (2016). Heat shock represses transcription of rRNA genes by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning. Nucleic Acids Res 44, 8144-8152.
  • Zhao, Z., Dammert, M.A., Grummt, I., and Bierhoff, H. (2016). lncRNA-induced nucleosome repositioning reinforces transcriptional repression of rRNA genes upon hypotonic stress. Cell Rep 14, 1876-1882
  • Parlato, R., and Bierhoff, H. (2015). Role of nucleolar dysfunction in neurodegenerative disorders: a game of genes? AIMS Molecular Science 2: 211-224. DOI: 10.3934/molsci.2015.3.211
  • Bierhoff, H., Dammert, M.A., Brocks, D., Dambacher, S., Schotta, G., and Grummt, I. (2014). Quiescence-induced lncRNAs trigger H4K20 trimethylation and transcriptional silencing. Mol Cell 54, 675-682.
  • Bierhoff, H., Postepska-Igielska, A., and Grummt, I. (2014). Noisy silence: Non-coding RNA and heterochromatin formation at repetitive elements. Epigenetics 9, 53-61.
  • Kiryk, A., Sowodniok, K., Kreiner, G., Rodriguez-Parkitna, J., Sonmez, A., Gorkiewicz, T., Bierhoff, H., Wawrzyniak, M., Janusz, A.K., Liss, B., et al. (2013). Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons. Front Cell Neurosci 7, 207.
  • Kreiner, G.*, Bierhoff, H.*, Armentano, M., Rodriguez-Parkitna, J., Sowodniok, K., Naranjo, J.R., Bonfanti, L., Liss, B., Schutz, G., Grummt, I., et al. (2013). A neuro-protective phase precedes striatal degeneration upon nucleolar stress. Cell Death Differ 20, 1455-1464.
  • * equal contribution
  • Bierhoff, H., Schmitz, K., Maass, F., Ye, J., and Grummt, I. (2010). Noncoding transcripts in sense and antisense orientation regulate the epigenetic state of ribosomal RNA genes. Cold Spring Harb Symp Quant Biol 75, 357-364.
  • Hoppe, S., Bierhoff, H., Cado, I., Weber, A., Tiebe, M., Grummt, I., and Voit, R. (2009). AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci U S A 106, 17781-17786.
  • Bierhoff, H., Dundr, M., Michels, A.A., and Grummt, I. (2008). Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I. Mol Cell Biol 28, 4988-4998.
  • Mayer, C., Bierhoff, H., and Grummt, I. (2005). The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev 19, 933-941.
  • Arabi, A., Wu, S., Ridderstrale, K., Bierhoff, H., Shiue, C., Fatyol, K., Fahlen, S., Hydbring, P., Soderberg, O., Grummt, I., et al. (2005). c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription. Nat Cell Biol 7, 303-310.
  • Pawlowski, A., Riedel, K.U., Klipp, W., Dreiskemper, P., Gross, S., Bierhoff, H., Drepper, T., and Masepohl, B. (2003). Yeast two-hybrid studies on interaction of proteins involved in regulation of nitrogen fixation in the phototrophic bacterium Rhodobacter capsulatus. J Bacteriol 185, 5240-5247.

 

Research Monographs

  • Bierhoff, H. (2014). Stichwort: Nicht-codierende RNA. Naturw. Rdsch. 67/12.