Publications

  • 2021
  • Greifenstein AA, Jo S, Bierhoff H. RNA:DNA triple helices: from peculiar structures to pervasive chromatin regulators. Essays Biochem. 2021 Apr 9:EBC20200089.
  • 2020
    Joshi G, Eberhardt AO, Lange L, Winkler R, Hoffmann S, Kosan C, Bierhoff H. 2020.
    Dichotomous Impact of Myc on rRNA Gene Activation and Silencing in B Cell
    Lymphomagenesis. Cancers 12(10):3009.
    Sharifi S, da Costa HFR, Bierhoff H. 2020. The circuitry between ribosome biogenesis
    and translation in stem cell function and ageing. Mech Ageing Dev 189: 111282
  • 2019
    Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y,
    Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K,
    Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M,
    Flanary VL, Ramkissoon A, Chow LML, Kiyokawa J, Mashimo T, Lucey G,
    Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-
    Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou
    D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ,
    Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I,
    Bierhoff H, Sasaki AT. 2019. IMP dehydrogenase-2 drives aberrant nucleolar
    activity and promotes tumorigenesis in glioblastoma. Nat Cell Biol 21: 1003-14
  • 2018
    Sharifi S, Bierhoff H. 2018. Regulation of RNA Polymerase I Transcription in
    Development, Disease, and Aging. Annu Rev Biochem 87: 51-73
    Kosan C, Heidel FH, Godmann M, Bierhoff H. 2018. Epigenetic Erosion in Adult Stem
    Cells: Drivers and Passengers of Aging. Cells 7
    Bierhoff H. 2018. Analysis of lncRNA-Protein Interactions by RNA-Protein Pull-Down
    Assays and RNA Immunoprecipitation (RIP). Methods Mol Biol 1686: 241-50
  • 2017
    Zhao Z, Bierhoff H. 2017. Nucleosome Positioning Assay. Bio-protocol 7: e2285
    Schnoder TM, Eberhardt J, Koehler M, Bierhoff HB, Weinert S, Pandey AD, Nimmagadda
    SC, Wolleschak D, Johrens K, Fischer T, Heidel FH. 2017. Cell autonomous
    expression of CXCL-10 in JAK2V617F-mutated MPN. J Cancer Res Clin Oncol
    143: 807-20
    Evsyukov V, Domanskyi A, Bierhoff H, Gispert S, Mustafa R, Schlaudraff F, Liss B,
    Parlato R. 2017. Genetic mutations linked to Parkinson's disease differentially
    control nucleolar activity in pre-symptomatic mouse models. Dis Model Mech 10:
    633-43
  • 2016
    Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y,
    Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A,
    Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt
    O, Lubbert M, Mallm JP, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhauser
    C, Oakes CC, Wang T, Plass C. 2017. DNMT and HDAC inhibitors induce cryptic
    transcription start sites encoded in long terminal repeats. Nat Genet 49: 1052-60
    Zhao Z, Dammert MA, Hoppe S, Bierhoff H, Grummt I. 2016. Heat shock represses rRNA

     

    synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome
    positioning. Nucleic Acids Res 44: 8144-52
    Zhao Z, Dammert MA, Grummt I, Bierhoff H. 2016. lncRNA-Induced Nucleosome
    Repositioning Reinforces Transcriptional Repression of rRNA Genes upon
    Hypotonic Stress. Cell Rep 14: 1876-82

  • 2015
    Parlato R, Bierhoff H. 2015. Role of nucleolar dysfunction in neurodegenerative disorders:
    a game of genes? AIMS Molecular Science 2: 211-24
    2014
    Bierhoff H, Postepska-Igielska A, Grummt I. 2014. Noisy silence: non-coding RNA and
    heterochromatin formation at repetitive elements. Epigenetics 9: 53-61
    Bierhoff H, Dammert MA, Brocks D, Dambacher S, Schotta G, Grummt I. 2014.
    Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional
    silencing. Mol Cell 54: 675-82
  • 2013 and earlier
    Kreiner G*, Bierhoff H*, Armentano M, Rodriguez-Parkitna J, Sowodniok K, Naranjo JR,
    Bonfanti L, Liss B, Schutz G, Grummt I, Parlato R. 2013. A neuroprotective phase
    precedes striatal degeneration upon nucleolar stress. Cell Death Differ 20: 1455-
    64
    *shared first authorship
    Kiryk A, Sowodniok K, Kreiner G, Rodriguez-Parkitna J, Sonmez A, Gorkiewicz T,
    Bierhoff H, Wawrzyniak M, Janusz AK, Liss B, Konopka W, Schutz G, Kaczmarek
    L, Parlato R. 2013. Impaired rRNA synthesis triggers homeostatic responses in
    hippocampal neurons. Front Cell Neurosci 7: 207
    Bierhoff H, Schmitz K, Maass F, Ye J, Grummt I. 2010. Noncoding transcripts in sense
    and antisense orientation regulate the epigenetic state of ribosomal RNA genes.
    Cold Spring Harb Symp Quant Biol 75: 357-64
    Hoppe S, Bierhoff H, Cado I, Weber A, Tiebe M, Grummt I, Voit R. 2009. AMP-activated
    protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad
    Sci U S A 106: 17781-6
    Bierhoff H, Dundr M, Michels AA, Grummt I. 2008. Phosphorylation by casein kinase 2
    facilitates rRNA gene transcription by promoting dissociation of TIF-IA from
    elongating RNA polymerase I. Mol Cell Biol 28: 4988-98
    Mayer C, Bierhoff H, Grummt I. 2005. The nucleolus as a stress sensor: JNK2 inactivates
    the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev 19:
    933-41
    Arabi A, Wu S, Ridderstrale K, Bierhoff H, Shiue C, Fatyol K, Fahlen S, Hydbring P,
    Soderberg O, Grummt I, Larsson LG, Wright AP. 2005. c-Myc associates with
    ribosomal DNA and activates RNA polymerase I transcription. Nat Cell Biol 7:
    303-10
    Pawlowski A, Riedel KU, Klipp W, Dreiskemper P, Gross S, Bierhoff H, Drepper T,
    Masepohl B. 2003. Yeast two-hybrid studies on interaction of proteins involved in
    regulation of nitrogen fixation in the phototrophic bacterium Rhodobacter
    capsulatus. J Bacteriol 185: 5240-7

Research Monographs

  • Bierhoff, H. (2014). Stichwort: Nicht-codierende RNA. Naturw. Rdsch. 67/12.